What kind of strategy should you use if you are 2 doubles players playing against 2 singles players? Would lobs be a good option?
In my opinion lobs would not be a good option, since they do not capitalize on the typical strengths of doubles players.
Assuming none of the players have glaring weaknesses and the differences are just in singles/doubles specialty, standard doubles play should be the strategy. That is, the usual mixture of poaching and varied formations. The effectiveness will come from the skill and experience in playing doubles as opposed to a specific type of shot.