Tottenham Hotspur's goal difference of +60 in 2016/17 season is the highest in Premier League history for a non-title winning side. Opta Stats
What is the highest goal difference for non-title winning side in other European leagues such as La Liga, Bundesliga etc?
Highest goal difference for title winning side is:
Premier league: Chelsea 71 (2009-10)
La liga: Real Madrid 89 (2011-12)
Bundesliga: Bayern Munich 80 (2012-13)
Serie A: N/A
Ligue 1: Paris Saint-Germain 83 (2015-16)