Has there ever been a one-hitter MLB game in which the hit is an inside-the-park home run?
Norichika Aoki's first Major League home run broke up a perfect game.
Aoki's homer traveled only 213 feet in the air, a line drive that skipped past Rockies left fielder Carlos Gonzalez and rolled all the way to the fence in the fourth inning on Friday night at Miller Park.
There ended up being a few more hits but that was the first that came in the fourth inning that day. That's the closest to what you are asking that I have heard of.